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 20.02.2009   Карта сайта     Language По-русски По-английски
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20.02.2009

Nature 457, 994-998 (19 February 2009) | doi:10.1038/nature07752; Received 25 September 2008; Accepted 24 December 2008



Travelling-wave nuclear magnetic resonance


David O. Brunner1, Nicola De Zanche1, Jürg Fröhlich2, Jan Paska2 & Klaas P. Pruessmann1




  1. Institute for Biomedical Engineering, University of Zürich and ETH Zürich, Gloriastrasse 35, 8092 Zürich, Switzerland
  2. Laboratory for Electromagnetic Fields and Microwave Electronics, ETH Zürich, Gloriastrasse 35, 8092 Zürich, Switzerland


Correspondence to: Klaas P. Pruessmann1 Correspondence and requests for materials should be addressed to K.P.P. (Email: pruessmann@biomed.ee.ethz.ch).





Nuclear magnetic resonance1, 2 (NMR) is one of the most versatile experimental methods in chemistry, physics and biology3, providing insight into the structure and dynamics of matter at the molecular scale. Its imaging variant—magnetic resonance imaging4, 5 (MRI)—is widely used to examine the anatomy, physiology and metabolism of the human body. NMR signal detection is traditionally based on Faraday induction6 in one or multiple radio-frequency resonators7, 8, 9, 10 that are brought into close proximity with the sample. Alternative principles involving structured-material flux guides11, superconducting quantum interference devices12, atomic magnetometers13, Hall probes14 or magnetoresistive elements15 have been explored. However, a common feature of all NMR implementations until now is that they rely on close coupling between the detector and the object under investigation. Here we show that NMR can also be excited and detected by long-range interaction, relying on travelling radio-frequency waves sent and received by an antenna. One benefit of this approach is more uniform coverage of samples that are larger than the wavelength of the NMR signal—an important current issue in MRI of humans at very high magnetic fields. By allowing a significant distance between the probe and the sample, travelling-wave interaction also introduces new possibilities in the design of NMR experiments and systems.



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