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 09.07.2009   Карта сайта     Language По-русски По-английски
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09.07.2009

Nature 460, 250-253 (9 July 2009) | doi:10.1038/nature08116; Received 5 February 2009; Accepted 1 May 2009



DNA sequence motifs for structure-specific recognition and separation of carbon nanotubes


Xiaomin Tu1, Suresh Manohar2, Anand Jagota2,3 & Ming Zheng1




  1. DuPont Central Research and Development, Wilmington, Delaware 19880, USA

  2. Department of Chemical Engineering and,

  3. Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania 18015, USA


Correspondence to: Ming Zheng1 Correspondence and requests for materials should be addressed to M.Z. (Email: ming.zheng@usa.dupont.com).





Single-walled carbon nanotubes (SWNTs) are a family of molecules that have the same cylindrical shape but different chiralities1. Many fundamental studies and technological applications2 of SWNTs require a population of tubes with identical chirality that current syntheses cannot provide. The SWNT sorting problem—that is, separation of a synthetic mixture of tubes into individual single-chirality components—has attracted considerable attention in recent years. Intense efforts so far have focused largely on, and resulted in solutions for, a weaker version of the sorting problem: metal/semiconductor separation3, 4. A systematic and general method to purify each and every single-chirality species of the same electronic type from the synthetic mixture of SWNTs is highly desirable, but the task has proven to be insurmountable to date. Here we report such a method, which allows purification of all 12 major single-chirality semiconducting species from a synthetic mixture, with sufficient yield for both fundamental studies and application development. We have designed an effective search of a DNA library of approx1060 in size, and have identified more than 20 short DNA sequences, each of which recognizes and enables chromatographic purification of a particular nanotube species from the synthetic mixture. Recognition sequences exhibit a periodic purine–pyrimidines pattern, which can undergo hydrogen-bonding to form a two-dimensional sheet, and fold selectively on nanotubes into a well-ordered three-dimensional barrel. We propose that the ordered two-dimensional sheet and three-dimensional barrel provide the structural basis for the observed DNA recognition of SWNTs.



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  • Harton Vladislav Vadim  honorary member of ISSC science council

  • Lichtenstain Alexandr Iosif  honorary member of ISSC science council

  • Novikov Dimirtii Leonid  honorary member of ISSC science council

  • Yakushev Mikhail Vasilii  honorary member of ISSC science council

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