Systems with coupled mechanical and optical or electrical degrees of freedom1, 2 have fascinating dynamics that, through macroscopic manifestations of quantum behaviour3, provide new insights into the transition between the classical and quantum worlds. Of particular interest is the back-action of electrons and photons on mechanical oscillators, which can lead to cooling and amplification of mechanical motion4, 5, 6. Furthermore, feedback, which is naturally associated with back-action, has been predicted to have significant consequences for the noise of a detector coupled to a mechanical oscillator7, 8. Recently it has also been demonstrated that such feedback effects lead to strong coupling between single-electron transport and mechanical motion in carbon nanotube nanomechanical resonators9, 10. Here we present noise measurements which show that the mesoscopic back-action of electrons tunnelling through a radio-frequency quantum point contact11 causes driven vibrations of the host crystal. This effect is a remarkable macroscopic manifestation of microscopic quantum behaviour, where the motion of a mechanical oscillator—the host crystal, which consists of on the order of 1020 atoms—is determined by statistical fluctuations of tunnelling electrons.