РОССИЙСКАЯ АКАДЕМИЯ НАУК

УРАЛЬСКОЕ ОТДЕЛЕНИЕ

ИНСТИТУТ ХИМИИ TBEPДОГО ТЕЛА
   
| | | | |
| | | |
 24.06.2011   Карта сайта     Language По-русски По-английски
Новые материалы
Экология
Электротехника и обработка материалов
Медицина
Статистика публикаци


24.06.2011

Organic chemistry: Triumph for unnatural synthesis




Journal name:

Nature

Volume:

474,

Pages:

459–460

Date published:

(23 June 2011)

DOI:

doi:10.1038/474459a


Published online







Nature crafts many molecules from common precursors, but this approach isn't always possible in chemical synthesis. A strategy for synthesizing a family of natural products succeeds by ignoring nature's blueprint. See Article p.461








Polyphenols are a group of structurally diverse compounds found in fruits, vegetables and plant-based food products such as tea, wine and chocolate. Because many polyphenols are antioxidants, they have been acclaimed as natural health-protecting agents, although the benefits to humans have yet to be proven. Nevertheless, some polyphenols have biological activities that make them potentially useful leads in the search for drugs against illnesses such as heart disease, cancer and Alzheimer's disease. Pharmaceutical research has been thwarted, however, by the fact that the most complex polyphenols are available from their natural sources in only limited quantities.


An obvious solution would be to prepare large quantities of polyphenols using chemical synthesis. This might seem a trivial task, given that many polyphenols are oligomers derived from just one or two precursor molecules, of which resveratrol (Fig. 1) is perhaps the best-known example. In fact, the structural complexity of resveratrol oligomers makes their chemical synthesis a daunting challenge. But on page 461 of this issue, Snyder et al.1 describe a major advance in polyphenol research: a daring but clever synthetic strategy that has enabled them to prepare a series of resveratrol trimers and tetramers — the highest-order resveratrol oligomers prepared to date.


Figure 1: A synthetic strategy for making resveratrol-derived polyphenols.

A synthetic strategy for making resveratrol-derived polyphenols.

 





Дизайн и программирование N-Studio 
А Б В Г Д Е Ё Ж З И Й К Л М Н О П Р С Т У Ф Х Ц Ч Ш Щ Ъ Ы Ь Э Ю Я
  • Chen Wev .  honorary member of ISSC science council

  • Harton Vladislav Vadim  honorary member of ISSC science council

  • Lichtenstain Alexandr Iosif  honorary member of ISSC science council

  • Novikov Dimirtii Leonid  honorary member of ISSC science council

  • Yakushev Mikhail Vasilii  honorary member of ISSC science council

  • © 2004-2019 ИХТТ УрО РАН
    беременность, мода, красота, здоровье, диеты, женский журнал, здоровье детей, здоровье ребенка, красота и здоровье, жизнь и здоровье, секреты красоты, воспитание ребенка рождение ребенка,пол ребенка,воспитание ребенка,ребенок дошкольного возраста, дети дошкольного возраста,грудной ребенок,обучение ребенка,родить ребенка,загадки для детей,здоровье ребенка,зачатие ребенка,второй ребенок,определение пола ребенка,будущий ребенок медицина, клиники и больницы, болезни, врач, лечение, доктор, наркология, спид, вич, алкоголизм православные знакомства, православный сайт творчeства, православные рассказы, плохие мысли, православные психологи рождение ребенка,пол ребенка,воспитание ребенка,ребенок дошкольного возраста, дети дошкольного возраста,грудной ребенок,обучение ребенка,родить ребенка,загадки для детей,здоровье ребенка,зачатие ребенка,второй ребенок,определение пола ребенка,будущий ребенок